Preferred Label : Anti-Claudin 18.2 Antibody-drug Conjugate SOT102;
NCIt synonyms : Anti-Claudin 18.2 ADC SOT102; Anti-CLDN18.2 ADC SOT102; ADC SO-N102; ADC SOT102; Anti-Claudin 18.2/PNU ADC SOT102;
NCIt definition : An antibody-drug conjugate (ADC) composed of an immunoglobulin G1 (IgG1) monoclonal
antibody directed against the tumor-associated antigen (TAA) claudin 18.2 (CLDN18.2;
A2 isoform of claudin-18) that is site-specifically conjugated, via a non-cleavable
amide/peptide linker, to a derivative of the cytotoxic anthracycline PNU-159682, with
potential antineoplastic activity. Upon administration of anti-CLDN18.2 ADC SOT102,
the antibody moiety specifically targets and binds to CLDN18.2 expressed on tumor
cells. Upon internalization, the anthracycline-based toxin intercalates into DNA and
interacts with topoisomerase II. This leads to an inhibition of DNA replication and
repair, and prevents RNA and protein synthesis. This kills the CLDN18.2-expressing
tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18,
is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly
confined to short-lived differentiated epithelial cells of the gastric mucosa.;
Molecule name : SOT-102; SO N102; SO-N102; SOT 102;
NCI Metathesaurus CUI : CL1799320;
Origin ID : C190788;
UMLS CUI : C5787246;
Semantic type(s)
- concept_is_in_subset
- has_target
