Preferred Label : Anti-claudin 18.2 Antibody-drug Conjugate LM-302;
NCIt synonyms : Anti-claudin 18.2 ADC LM-302; Anti-CLDN18.2 ADC LM-302;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) claudin 18.2 (CLDN18.2; A2 isoform of claudin-18)
conjugated via a cleavable linker, to the microtubule-disrupting cytotoxic agent monomethyl
auristatin E (MMAE), with potential antineoplastic activity. Upon administration,
anti-CLDN18.2 ADC LM-302 specifically targets and binds to CLDN18.2 expressed on tumor
cells. Upon internalization and the release of MMAE, MMAE targets and binds to tubulin,
and inhibits microtubule polymerization. This results in G2/M phase cell cycle arrest
and apoptosis in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein
and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells.
Its expression in healthy tissues is strictly confined to short-lived differentiated
epithelial cells of the gastric mucosa.;
Molecule name : LM-302; LM 302;
NCI Metathesaurus CUI : CL1778265;
Origin ID : C185853;
UMLS CUI : C5667024;
Semantic type(s)
- concept_is_in_subset
- has_target
