NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) claudin 18.2 (CLDN18.2; A2 isoform of claudin-18)
conjugated via a cleavable linker, to the microtubule-disrupting cytotoxic agent monomethyl
auristatin E (MMAE), with potential antineoplastic activity. Upon administration,
tecotabart vedotin specifically targets and binds to CLDN18.2 expressed on tumor cells.
Upon internalization and the release of MMAE, MMAE targets and binds to tubulin, and
inhibits microtubule polymerization. This results in G2/M phase cell cycle arrest
and apoptosis in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein
and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells.
Its expression in healthy tissues is strictly confined to short-lived differentiated
epithelial cells of the gastric mucosa.;
UNII : 9GK5GYD8DQ;
CAS number : 2823357-33-9;
Molecule name : LM-302; LM 302; TPX 4589; TPX-4589;
Currated CISMeF NLP mapping