NCIt definition : A lipid nanoparticle (LNP) encapsulating a messenger RNA (mRNA) encoding for a monoclonal
antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2;
A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities.
Upon administration, mRNA-encoded anti-claudin18.2 monoclonal antibody BNT141 binds
to the plasma membrane of cells and releases the mRNA into the cells. The mRNA is
then translated by ribosomes to produce the anti-CLDN18.2 monoclonal antibody. The
antibody specifically targets, binds to and inhibits CLDN18.2 expressed on tumor cells.
This may kill CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein
and stomach-specific isoform of claudin-18, is overexpressed on a variety of tumor
cells, but its expression in healthy tissues is strictly confined to short-lived differentiated
epithelial cells of the gastric mucosa.;
Semantic type(s)