Preferred Label : Anti-CLDN18.2 Heavy Chain Antibody Fc Fusion Protein DR30303;
NCIt synonyms : Fusion Protein DR30303; Anti-CLDN18.2 VHH-Fc DR30303; VHH-Fc DR30303;
NCIt definition : A fusion protein composed of a recombinant humanized anti-Claudin18.2 (CLDN18.2; A2
isoform of claudin-18) heavy chain antibody (VHH) fused to an engineered immunoglobulin
gamma-1 (IgG1) Fc fragment, with potential immunostimulating and antineoplastic activities.
Upon administration, anti-CLDN18.2 heavy chain antibody Fc fusion protein DR30303
specifically targets, binds to and inhibits CLDN18.2 expressed on tumor cells. The
binding induces antibody-dependent cellular cytotoxicity (ADCC) and may kill CLDN18.2-expressing
tumor cells and inhibit tumor cell proliferation. CLDN18.2, a tight junction protein
and stomach-specific isoform of claudin-18, is overexpressed on a variety of tumor
cells. Its expression in healthy tissues is strictly confined to short-lived differentiated
epithelial cells of the gastric mucosa.;
Molecule name : DR 30303; DR-30303;
NCI Metathesaurus CUI : CL1905850;
Origin ID : C198698;
UMLS CUI : C5854370;
Semantic type(s)
- concept_is_in_subset
- has_target
