NCIt definition : A monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin18.2
(CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic
activities. Upon administration, anti-CLDN18.2 monoclonal antibody TORL-2-307-MAB
specifically targets, binds to and inhibits CLDN18.2 expressed on tumor cells. This
may kill CLDN18.2-expressing tumor cells and inhibit tumor cell proliferation. CLDN18.2,
a tight junction protein and stomach-specific isoform of claudin-18, is expressed
on a variety of tumor cells. Its expression in healthy tissues is strictly confined
to short-lived differentiated epithelial cells of the gastric mucosa.;
Semantic type(s)