NCIt definition : A monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin18.2
(CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic
activities. Upon administration, anti-CLDN18.2 monoclonal antibody M108 specifically
targets, binds to and inhibits CLDN18.2 expressed on tumor cells. The binding induces
antibody-dependent cellular cytotoxicity (ADCC) and may kill CLDN18.2-expressing tumor
cells and inhibit cell proliferation. CLDN18.2, a tight junction protein and stomach-specific
isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in
healthy tissues is strictly confined to short-lived differentiated epithelial cells
of the gastric mucosa.;
UNII : 6THJ337EJ9;
CAS number : 15589-31-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 15589-31-8
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Semantic type(s)