NCIt definition : A monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin18.2
(CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic
activities. Upon administration, anti-CLDN18.2 monoclonal antibody M108 specifically
targets, binds to and inhibits CLDN18.2 expressed on tumor cells. The binding induces
antibody-dependent cellular cytotoxicity (ADCC) and may kill CLDN18.2-expressing tumor
cells and inhibit cell proliferation. CLDN18.2, a tight junction protein and stomach-specific
isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in
healthy tissues is strictly confined to short-lived differentiated epithelial cells
of the gastric mucosa.;
Semantic type(s)