" /> Autologous Anti-Claudin18.2 CAR T-cells LB1908 - CISMeF





Preferred Label : Autologous Anti-Claudin18.2 CAR T-cells LB1908;

NCIt synonyms : Autologous Claudin 18.2-targeting CAR-T Cells LB1908; Claudin 18.2-targeted Autologous Chimeric Antigen Receptor T-cells LB1908; Autologous Anti-CLDN18.2 CAR T-cells LB1908; Autologous Anti-Claudin18.2 CAR T Cells LB1908;

NCIt definition : A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CLDN18.2 CAR T-cells LB1908 specifically recognize and induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa.;

Molecule name : LB-1908; LB 1908;

NCI Metathesaurus CUI : CL1905552;

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12/05/2024


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