Preferred Label : Anti-CLDN18.2 CAR-T Cells AZD6422;
NCIt synonyms : Anti-Claudin18.2 CAR T Cells AZD6422; Anti-Claudin18.2 CAR-T Cells AZD6422; Anti-Claudin18.2 CAR T-cells AZD6422;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric
antigen receptor (CAR) targeting the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2;
A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities.
Upon administration, anti-CLDN18.2 CAR-T cells AZD6422 specifically recognize and
bind to CLDN18.2-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte
(CTL)-mediated killing of CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction
protein and stomach-specific isoform of claudin-18, is overexpressed on a variety
of tumor cells, but its expression in healthy tissues is strictly confined to short-lived
differentiated epithelial cells of the gastric mucosa.;
Molecule name : AZD-6422; AZD 6422;
Origin ID : C201144;
- concept_is_in_subset
- has_target