Preferred Label : Anti-CLDN18.2 CAR T Cells LY011;
NCIt synonyms : LY-011;
NCIt definition : A preparation of allogeneic T-lymphocytes that have been genetically modified to express
a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) Claudin18.2
(CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic
activities. Upon administration, the anti-CLDN18.2 CAR T-cells LY011 specifically
recognize and bind to CLDN18.2-expressing tumor cells. This may result in a specific
cytotoxic T-lymphocyte (CTL)-mediated killing of CLDN18.2-expressing tumor cells.
CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is
overexpressed on a variety of tumor cells, but its expression in healthy tissues is
strictly confined to short-lived differentiated epithelial cells of the gastric mucosa.;
Molecule name : LY011; LY 011;
NCI Metathesaurus CUI : CL1664835;
Origin ID : C181995;
UMLS CUI : C5557404;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
