Preferred Label : Anti-Claudin 18.2 Antibody-drug Conjugate EO-3021;
NCIt synonyms : Anti-Claudin 18.2 Antibody-drug Conjugate SYSA1801; Anti-CLDN18.2 ADC EO-3021;
NCIt related terms : EO-3021;
NCIt definition : An antibody-drug conjugate (ADC) composed of a human monoclonal antibody directed
against the tumor-associated antigen (TAA) Claudin 18.2 (CLDN18.2; A2 isoform of claudin-18)
conjugated to the microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE),
with potential antineoplastic activity. Upon administration of anti-CLDN18.2 ADC EO-3021,
the anti-CLDN18.2 monoclonal antibody moiety specifically targets and binds to CLDN18.2
expressed on tumor cells. Upon internalization and the release of MMAE, MMAE targets
and binds to tubulin, and inhibits microtubule polymerization. This results in G2/M
phase cell cycle arrest and apoptosis in CLDN18.2-expressing tumor cells. CLDN18.2,
a tight junction protein and stomach-specific isoform of claudin-18, is expressed
on a variety of tumor cells. Its expression in healthy tissues is strictly confined
to short-lived differentiated epithelial cells of the gastric mucosa.;
UNII : CBF5R8TXD9;
Molecule name : EO-3021; SYSA-1801; EO 3021; SYSA 1801;
NCI Metathesaurus CUI : CL1915454;
Origin ID : C201073;
UMLS CUI : C5853355;
Semantic type(s)
- concept_is_in_subset
- has_target
