NCIt definition : A recombinant humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against
the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18),
with potential immunostimulating and antineoplastic activities. Upon administration,
anti-CLDN18.2 monoclonal antibody MIL93 specifically targets, binds to and inhibits
CLDN18.2 expressed on tumor cells. This may kill CLDN18.2-expressing tumor cells and
inhibit cell proliferation. CLDN18.2, a tight junction protein and stomach-specific
isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in
healthy tissues is strictly confined to short-lived differentiated epithelial cells
of the gastric mucosa.;
Semantic type(s)