Preferred Label : Anti-Claudin 18.2 Antibody-drug Conjugate BL-M05D1;
NCIt synonyms : Anti-Claudin 18.2/Ed-04 ADC BL-M05D1; Anti-CLDN18.2 ADC BL-M05D1;
NCIt definition : An antibody-drug conjugate (ADC) composed of a wild-type Fc-containing immunoglobulin
(IgG) monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin
18.2 (CLDN18.2; A2 isoform of claudin-18) (5103F3) conjugated, via a cathepsin B cleavable
linker, to the camptothecin derivative and topoisomerase 1 inhibitor Ed-04, with potential
antineoplastic activity. Upon administration of anti-CLDN18.2 ADC BL-M05D1, the anti-CLDN18.2
monoclonal antibody moiety specifically targets and binds to CLDN18.2 expressed on
tumor cells. Upon binding, internalization and linker cleavage, Ed-04 is released
and inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and
resulting in cell cycle arrest and apoptosis in tumor cells expressing CLDN18.2. In
addition, BL-M05D1 may mediate antibody-dependent cellular cytotoxicity (ADCC) and
complement-dependent cytotoxicity (CDC). CLDN18.2, a tight junction protein and stomach-specific
isoform of claudin-18, is overexpressed on a variety of tumor cells. Its expression
in healthy tissues is strictly confined to short-lived differentiated epithelial cells
of the gastric mucosa.;
Molecule name : BL M05D1; BL-M05D1;
Origin ID : C215079;
concept_is_in_subset
- has_target
