NCIt definition : A humanized monoclonal antibody directed against the tumor-associated antigen (TAA)
Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating
and antineoplastic activities. Upon administration, anti-CLDN18.2 monoclonal antibody
SPX-101 specifically targets, binds to and inhibits CLDN18.2 expressed on tumor cells.
This may kill and inhibit proliferation of CLDN18.2-expressing tumor cells. SPX-101
may trigger antibody-dependent cellular cytotoxicity (ADCC). CLDN18.2, a tight junction
protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor
cells. Its expression in healthy tissues is strictly confined to short-lived differentiated
epithelial cells of the gastric mucosa.;
Semantic type(s)