Preferred Label : Anti-Claudin18.2/MMAE Antibody-drug Conjugate TORL-2-307-ADC;
NCIt synonyms : ADC TORL-2-307-ADC; CLDN18.2-307-ADC; Anti-CLDN18.2/MMAE ADC TORL-2-307-ADC; Anti-CLDN18.2 ADC TORL-2-307-ADC;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18)
conjugated, via a cleavable linker, to the microtubule-disrupting cytotoxic agent
monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration,
anti-CLDN18.2/MMAE ADC TORL-2-307-ADC specifically targets and binds to CLDN18.2 expressed
on tumor cells. Upon internalization and the release of MMAE, MMAE targets and binds
to tubulin, and inhibits microtubule polymerization. This results in G2/M phase cell
cycle arrest and apoptosis in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction
protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor
cells. Its expression in healthy tissues is strictly confined to short-lived differentiated
epithelial cells of the gastric mucosa.;
Molecule name : TORL 2-307-ADC; TORL-2-307-ADC;
NCI Metathesaurus CUI : CL1773925;
Origin ID : C185565;
UMLS CUI : C5667004;
Semantic type(s)
- concept_is_in_subset
- has_target
