NCIt definition : A bispecific antibody directed against the tumor-associated antigen (TAA) Claudin18.2
(CLDN18.2; A2 isoform of claudin-18) and the human T-cell surface antigen CD3, with
potential immunostimulatory and antineoplastic activities. Upon administration, anti-CD3/anti-CLDN18.2
bispecific antibody IBI389 simultaneously binds to both CD3-expressing T-cells and
CLDN18.2-expressing cancer cells, thereby crosslinking CLDN18.2-expressing tumor cells
and cytotoxic T-lymphocytes (CTLs). This results in the activation and proliferation
of T-cells and causes CTL-mediated cell lysis of CLDN18.2-expressing tumor cells.
CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is
expressed on a variety of tumor cells. Its expression in healthy tissues is strictly
confined to short-lived differentiated epithelial cells of the gastric mucosa.;
Semantic type(s)