" /> Zolbetuximab - CISMeF





Preferred Label : Zolbetuximab;

NCIt synonyms : Claudiximab;

NCIt definition : A chimeric immunoglobulin G1 (IgG1) monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, zolbetuximab specifically targets and binds to CLDN18.2 expressed on tumor cells. This may kill CLDN18.2-expressing tumor cells by antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), and inhibit cell proliferation. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa.;

UNII : TF5MPQ8WGY;

CAS number : 1496553-00-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1496553-00-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : IMAB-362; IMAB 362;

NCI Metathesaurus CUI : CL554291;

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15/05/2024


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