Preferred Label : Anti-Claudin 18.2 Antibody-drug Conjugate SKB315;
NCIt synonyms : Anti-Claudin 18.2 ADC SKB315; Anti-CLDN18.2 ADC SKB315; Anti-Claudin 18.2 ADC MK-1200; Anti-CLDN18.2 ADC MK-1200;
NCIt related terms : Anti-Claudin 18.2 Antibody-drug Conjugate MK-1200;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) claudin 18.2 (CLDN18.2; A2 isoform of claudin-18)
that is site-specifically conjugated, via a stable linker, to a cytotoxic DNA topoisomerase
I (Top I) inhibitor, with potential antineoplastic activity. Upon administration of
anti-CLDN18.2 ADC MK-1200, the antibody moiety specifically targets and binds to CLDN18.2
expressed on tumor cells. Upon internalization and the release of the Top I inhibitor,
the Top I inhibitor targets and binds to DNA topoisomerase I, thereby stabilizing
the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition
of DNA replication and apoptosis in CLDN18.2-expressing tumor cells. CLDN18.2, a tight
junction protein and stomach-specific isoform of claudin-18, is expressed on a variety
of tumor cells. Its expression in healthy tissues is strictly confined to short-lived
differentiated epithelial cells of the gastric mucosa.;
Molecule name : SKB 315; SKB-315; MK 1200; MK-1200;
NCI Metathesaurus CUI : CL1792363;
Origin ID : C187690;
UMLS CUI : C5706433;
Semantic type(s)
- concept_is_in_subset
- has_target
