Preferred Label : Givastomig;
NCIt synonyms : CLDN18.2-4-1BB Bispecific Antibody TJ-CD4B; Anti-CLDN18.2/Anti-4-1BB Bispecific Antibody TJ-CD4B; Anti-claudin18.2/4-1BB Bispecific Antibody TJ-CD4B; CLDN18.2 x 4-1BB BsAb TJ-CD4B; Anti-claudin18.2/Anti-4-1BB Bispecific Antibody TJ-CD4B;
NCIt definition : A bispecific antibody composed of a human, Fc-silenced immunoglobulin G1 (IgG1) monoclonal
antibody targeting the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform
of claudin-18) fused with a single chain variable fragment (scFv) targeting 4-1BB
(CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential
immunostimulating and antineoplastic activities. Upon administration, givastomig simultaneously
targets and binds to CLDN18.2 expressed on tumor cells and 4-1BB expressed on a variety
of leukocyte subsets including activated T-lymphocytes. Upon CLDN18.2 binding, the
4-1BB activation signal is induced and TJ-CD4B acts as a conditional 4-1BB agonist
in the tumor microenvironment (TME), resulting in T-cell co-stimulation and T-lymphocyte-mediated
anti-tumor activity. CLDN18.2, a tight junction protein and stomach-specific isoform
of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy
tissues is strictly confined to short-lived differentiated epithelial cells of the
gastric mucosa. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor
superfamily, is an inducible costimulatory receptor that plays a key role in T-cell
proliferation, survival and cytolytic activity.;
UNII : 8MSM5N7RMK;
CAS number : 2762499-30-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2762499-30-7
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : TJ-CD4B; ABL111; TJ033721;
NCI Metathesaurus CUI : CL1663495;
Origin ID : C180884;
UMLS CUI : C5556689;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
