Preferred Label : Iodine I 124 18B10(10L);
NCIt synonyms : 124I-18B10(10L); [124I]-18B10(10L);
NCIt definition : A radioconjugate composed of an antibody directed against the tumor-associated antigen
(TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), and conjugated with the radioisotope
iodine I 124, that can potentially be used as an imaging agent for positron emission
tomography (PET)/computed tomography (CT). Upon administration, the antibody moiety
of iodine I 124 18B10(10L) selectively targets and binds to CLDN18.2. The CLDN18.2-expressing
tumor cells can then be visualized using PET/CT. CLDN18.2, a tight junction protein
and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells.
Its expression in healthy tissues is strictly confined to short-lived differentiated
epithelial cells of the gastric mucosa.;
NCI Metathesaurus CUI : CL1663331;
Origin ID : C180688;
UMLS CUI : C5556561;
Semantic type(s)
- concept_is_in_subset
- has_target
