KRT18 wt Allele

Preferred Label : KRT18 wt Allele;

NCIt synonyms : CK18; PIG46; K18; Keratin 18 wt Allele; CYK18; Cell Proliferation-Inducing Gene 46;

NCIt definition : Human KRT18 wild-type allele is located in the vicinity of 12q13 and is approximately 4 kb in length. This allele, which encodes keratin, type I cytoskeletal 18 protein, is involved in both the negative regulation of apoptosis and intermediate filament structure. Mutations in the gene are associated with cryptogenic cirrhosis.;

GenBank Accession Number : NM_199187;

Details

Origin ID

C111867;

UMLS CUI

C3829362;

Automatic exact mappings (from CISMeF team)
- CK18 [MedDRA LLT]
- K-18 conjugate [MeSH Supplementary Concept]
- Keratin 18, type I [OMIM gene]
OMIM relation
- Keratin 18, type I [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 12q13 [NCIt concept]
gene_is_element_in_pathway
- Pathogenic Escherichia coli Infection Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Movement Process [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- Cytoskeletal Process [NCIt concept]
- Keratinization [NCIt concept]
- Membrane Protein Traffic [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Regulation of Cell Shape [NCIt concept]

Keyword's position in hierarchy(ies) :

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