Unconventional Myosin-Ig

Preferred Label : Unconventional Myosin-Ig;

NCIt synonyms : Myosin-Ig; MYO1G; HA2; mHag HA-2; HA-2; Minor Histocompatibility Antigen HA-2; Myosin IG;

NCIt definition : Unconventional myosin-Ig (1018 aa, 116 kDa) is encoded by the human MYO1G gene. This protein is involved in membrane/cytoskeletal interactions that are required for immune responses to rare antigens.;

NCIt note : The MHC class I HLA-A*0201 restricted HA-2 antigenic peptide within the canonical form of unconventional myosin-Ig is comprised of the nonapeptide sequence YIGEVLVSV (the second V represents valine at residue 49) and is referred to as MYO1G(V). There is a MYO1G variant with the sequence YIGEVLVSM (where valine-49 has been mutated to methionine) that is referred to as MYO1G(M), this amino acid change (V49M) results in a failure of the nonapeptide to be presented at the surface of cells that express MYO1G(M) endogenously. (J Immunol. 2001;167:3223-30.);

NCI Metathesaurus CUI : CL408922;

PubMed : 11544309;

Details

Origin ID

C190706;

UMLS CUI

C1099491;

OMIM relation
- Myosin ig [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MYO1G protein, human [MeSH Supplementary Concept]
- MYO1G protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytoskeletal Gene [NCIt concept]
- MYO1G Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoskeleton [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Actin-Binding Protein [NCIt concept]
gene_product_has_gene_product_variant
- MYO1G NP_149043.2:p.V49M [NCIt concept]
- MYO1G Protein Variant [NCIt concept]
gene_product_is_element_in_pathway
- Pathogenic Escherichia coli Infection Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Migration Induction [NCIt concept]
- Cell Movement Process [NCIt concept]
- Cytoskeletal Process [NCIt concept]
- Immune System Process [NCIt concept]
- Phagocytosis [NCIt concept]
- Regulation of Cell Shape [NCIt concept]
is_target
- Allogeneic Anti-HA-2 TCR-engineered T-cells TSC-101 [NCIt concept]

Keyword's position in hierarchy(ies) :

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