Preferred Label : Allogeneic Anti-HA-2 TCR-engineered T-cells TSC-101;
NCIt synonyms : T-cell Receptor Engineered Donor T-Cells TSC-101; HA-2-targeting TCR-T-cells TSC-101; Allogeneic T-cell Receptor-engineered T-cells TSC-101;
NCIt definition : A preparation of donor-derived T-lymphocytes that have been genetically engineered
to express a T-cell receptor (TCR) specific for HLA-A*02:01-restricted minor histocompatibility
antigen HA-2 (HA2), with potential immunomodulating and antineoplastic activities.
Following allogeneic haploidentical hematopoietic cell transplantation (HCT) in HLA-A*02:01
positive patients, allogeneic anti-HA-2 TCR-engineered T-cells TSC-101 specifically
recognize and bind to HA-2 expressed on tumor cells. This may lead to cytotoxic T-lymphocyte
(CTL)-mediated elimination of tumor cells expressing HA-2. HA-2 is a lineage-specific
antigen found on leukemia cells.;
Molecule name : TSC-101; TSC 101;
NCI Metathesaurus CUI : CL1799390;
Origin ID : C190705;
UMLS CUI : C5783871;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
