SRC Substrate Cortactin

Preferred Label : SRC Substrate Cortactin;

NCIt synonyms : SRC8; Amplaxin; p80/85 SRC Substrate; EMS1; Oncogene EMS1; Mammary Tumor and Squamous Cell Carcinoma-Associated Protein; EMS1 Protein; CTTN; Cortactin;

NCIt definition : Src substrate cortactin (550 aa, 62 kDa) is encoded by the human CTTN gene. This protein is involved in the regulation of both the interactions between adherens junction components and cytoskeletal organization.;

NCIt note : Cortactin may organize epithelial cell structure; it regulates interactions between adherens junction components and interacts with the cytoskeleton. It may interact with SHANK2 and SHANK3 via its SH2 domain. A substrate for pp60v-SRC, cortactin tyrosine phosphorylation may regulate cell growth. EGF enhances p85 phosphorylation and causes p80 to p85 conversion. Posttranslational modification of Cortactin coincides with redistribution to cell-matrix contact sites. Cortactin is degraded during apoptosis in a caspase-dependent manner. (from Swiss-Prot, OMIM, and NCI);

Details

Origin ID

C17689;

UMLS CUI

C1533647;

Currated CISMeF NLP mapping
- cortactin [MeSH Descriptor]
- cortactin [MeSH concept]
OMIM relation
- Cortactin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CTTN protein, human [MeSH concept]
- CTTN protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CTTN Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Epithelium [NCIt concept]
gene_product_has_biochemical_function
- Actin-Binding Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- SH2 Domain [NCIt concept]
- SH3 Domain [NCIt concept]
gene_product_is_element_in_pathway
- Adherens Junction Formation Pathway [NCIt concept]
- Agrin Pathway [NCIt concept]
- Bacterial Invasion of Epithelial Cell Pathway [NCIt concept]
- FGF Signaling Pathway [NCIt concept]
- N-Cadherin Signaling Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- Pathogenic Escherichia coli Infection Pathway [NCIt concept]
- Shigellosis Pathway [NCIt concept]
- Syndecan-3-Mediated Signaling Pathway [NCIt concept]
- Tight Junction Assembly Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Breast Squamous Cell Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytoskeletal Modeling [NCIt concept]
- Regulation of Cell Shape [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients