Toll-like receptor 4

Preferred Label : Toll-like receptor 4;

Symbol : TLR4;

CISMeF acronym : TLR4;

Type : Gene;

Alternative titles and symbols : Toll, drosophila, homolog of; TOLL;

Description : In Drosophila, the Toll transmembrane receptor plays a central role in the signaling pathways that control dorsal-ventral axis formation and the innate nonspecific immune response. TLR4, the human homolog of Drosophila Toll, is a type I transmembrane protein with an extracellular domain consisting of a leucine-rich repeat region and an intracellular domain homologous to that of human interleukin-1 receptor (IL1R; 147810). Signaling through TLR4 and Toll parallels the signaling pathway induced by IL1R in mammalian cells in that both signal through the NF-kappa-B (see 164011) pathway (summary by Medzhitov et al., 1997).;

Ensembl ID : ENSG00000136869;

Prefixed ID : *603030;

Details

Origin ID

603030;

UMLS CUI

C1336636;

Automatic exact mappings (from CISMeF team)
- TLR4 Gene [NCIt concept]
- TLR4 wt Allele [NCIt concept]
- toll like receptor 4 [ORDO Gene]
- toll like receptor 4 [HGNC gene]
Currated CISMeF NLP mapping
- Toll-Like Receptor 4 [NCIt concept]
- Toll-Like receptor 4 [MeSH concept]
- toll-like receptor 4 [MeSH Descriptor]
HGNC gene
- toll like receptor 4 [HGNC gene]
NCIt concept(s)
- TLR4 Gene [NCIt concept]
- TLR4 wt Allele [NCIt concept]
- Toll-Like Receptor 4 [NCIt concept]
ORDO concept(s)
- toll like receptor 4 [ORDO Gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- TLR4 Gene [NCIt concept]
- toll like receptor 4 [HGNC gene]

Keyword's position in hierarchy(ies) :

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