CCL5 wt Allele

Preferred Label : CCL5 wt Allele;

NCIt synonyms : D17S136E; MGC17164; TCP228; Chemokine (C-C Motif) Ligand 5 wt Allele; SISd; SIS-delta; SCYA5; RANTES; eoCP; Chemokine, CC Motif, Ligand 5 Gene; Small Inducible Cytokine Subfamily A, Member 5 Gene; Regulated Upon Activation, Normally T-Expressed, and Presumably Secreted Gene; Small Inducible Cytokine A5 (RANTES) Gene; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 5 Gene;

NCIt definition : Human CCL5 wild-type allele is located within 17q11.2-q12 and is approximately 36 kb in length. This allele, which encodes C-C motif chemokine 5 protein, plays a role in immune cell chemotaxis and histamine release.;

NCIt note : The cytokine encoded by CCL5 functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. Further, it causes histamine release from basophils and activates eosinophils.;

GenBank Accession Number : NM_002985;

Details

Origin ID

C49749;

UMLS CUI

C1704901;

Currated CISMeF NLP mapping
- RANTES (9-68) [MeSH concept]
- RANTES (9-68) [MeSH Supplementary Concept]
OMIM relation
- Chemokine, CC motif, ligand 5 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 17: 31231490-31222611 [NCIt concept]
gene_in_chromosomal_location
- 17q11.2-q12 [NCIt concept]
gene_is_element_in_pathway
- Allergy Chemokine Network Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Cytosolic DNA-Sensing Pathway [NCIt concept]
- Epithelial Cell Signaling Pathway in Helicobacter pylori Infection [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- Prion Disease Pathway [NCIt concept]
- Syndecan-1-Mediated Signaling Pathway [NCIt concept]
- Syndecan-4-Mediated Signaling Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Antiviral Response [NCIt concept]
- Cell Motility [NCIt concept]
- Chemotactic Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Intercellular Communication Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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