Preferred Label : Allergy Chemokine Network Pathway;
NCIt related terms : The Role of Eosinophils in the Chemokine Network of Allergy;
Alternative definition : BIOCARTA: The inflammatory response associated with asthma is characterized by the
recruitment of eosinophils from the bronchial microcirculation in response to the
regulated local production of chemoattractant molecules. Although several chemical
mediators are active upon eosinophils in vitro, a central role in eosinophil accumulation
in vivo is emerging for the C-C chemokine eotaxin, which was first identified in a
guinea pig model of allergic airway inflammation using protein purification and microsequencing.
Eotaxin is the dominant eosinophil-selective chemoattractant in this model, acting
to cause both local eosinophil recruitment to the lung, and the release of a rapidly
mobilizable pool of bone marrow eosinophils in cooperation with IL-5. Eotaxin and
eotaxin-2 are potent stimulators of eosinophils, signaling exclusively via high affinity
binding to the receptor CCR3. C-C chemokines, including MCP-3, MCP-4, and RANTES,
also stimulate eosinophils via CCR3, although they show less leukocyte selectivity
as they additionally signal via other chemokine receptors expressed on a range of
leukocytes, including lymphocytes and monocytes. CCR3 is expressed in high numbers
on eosinophils and is thought to be the major eosinophil chemokine receptor. Blockade
of CCR3 in vivo inhibits eosinophil recruitment in response to eotaxin in both the
guinea pig and mouse. More recently, CCR3 expression has been demonstrated on basophils
and Th2-type T cells, suggesting possible roles for CCR3 in the genesis and maintenance
of allergic inflammation. CCR3 is therefore a major target for anti-inflammatory drug
development. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_eosinophilsPathway;
Origin ID : C39064;
UMLS CUI : C1510856;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
