C-C Motif Chemokine 5

Preferred Label : C-C Motif Chemokine 5;

NCIt synonyms : MGC17164; CCL5; D17S136E; T-Cell RANTES Protein; SIS-delta; RANTES; TCP228; SCYA5; T-Cell Specific Protein p288; SISd; Chemokine (C-C Motif) Ligand 5; T-Cell-Specific Protein RANTES; Eosinophil Chemotactic Cytokine; Beta-Chemokine RANTES; T-Cell Specific RANTES; Small Inducible Cytokine A5; T-Cell Specific RANTES Protein; Small Inducible Cytokine-A5; Small-Inducible Cytokine A5; EoCP;

NCIt definition : C-C motif chemokine 5 (91 aa, 10 kDa) is encoded by the human CCL5 gene. This protein plays a role in both the release of histamine and chemoattraction of monocytes, memory T-helper cells and eosinophils.;

NCIt note : C-C motif chemokine 5 is cleaved into the following 2 chains: RANTES(3-68) and RANTES(4-68). (UniProt); C-C motif chemokine 5 is one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. (EntrezGene);

Details

Origin ID

C20483;

UMLS CUI

C1436337;

Currated CISMeF NLP mapping
- RANTES (9-68) [MeSH concept]
- RANTES (9-68) [MeSH Supplementary Concept]
OMIM relation
- Chemokine, CC motif, ligand 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CCL5 protein, human [MeSH concept]
- CCL5 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- CC Cytokine Gene [NCIt concept]
- CCL5 Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
gene_product_has_associated_anatomy
- Central Nervous System [NCIt concept]
- Epithelial Cell [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_is_element_in_pathway
- Allergy Chemokine Network Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Cytosolic DNA-Sensing Pathway [NCIt concept]
- Epithelial Cell Signaling Pathway in Helicobacter pylori Infection [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- Prion Disease Pathway [NCIt concept]
- Syndecan-1-Mediated Signaling Pathway [NCIt concept]
- Syndecan-4-Mediated Signaling Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antiviral Response [NCIt concept]
- Cell Motility [NCIt concept]
- Chemotactic Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Maturation [NCIt concept]

Keyword's position in hierarchy(ies) :

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