Calreticulin - CISMeF

Preferred Label : Calreticulin;

NCIt synonyms : CRP55; grp60; Calregulin; ERp60; HACBP; Endoplasmic Reticulum Resident Protein 60; CALR; Autoantigen Ro; Complement Component C1q Receptor;

NCIt definition : Calreticulin (417 aa, 48 kDa) is encoded by the human CALR gene. This protein plays a role in protein folding.;

NCIt note : Increased titers of autoantibodies to calreticulin are found in systemic lupus erythematosus and in infants with complete congenital heart block. Older reports referred to calreticulin as an Ro/SS-A antigen but this was later disproven. (Entrez Gene and UniProt);

Détails

Origin ID

C95315;

UMLS CUI

C3529617;

Currated CISMeF NLP mapping
- calreticulin [MeSH Descriptor]
- calreticulin [MeSH concept]
OMIM relation
- Calreticulin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CALR protein, human [MeSH concept]
- CALR protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CALR Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_gene_product_variant
- CALR NP_004334.1:p.K385fs*47 [NCIt concept]
- CALR NP_004334.1:p.L367fs*46 [NCIt concept]
- CALR Protein Variant [NCIt concept]
gene_product_is_element_in_pathway
- Antigen Processing and Presentation Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- NFAT Pathway [NCIt concept]
- Phagocytosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Calcium Binding [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Phagocytosis Induction [NCIt concept]
- Protein Folding [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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