Plasminogen Activator Inhibitor 1

Preferred Label : Plasminogen Activator Inhibitor 1;

NCIt synonyms : PAI-1; PLANH1; Plasminogen Activator Inhibitor Type 1; PAI1; Endothelial Plasminogen Activator Inhibitor; SERPINE1; Serpin E1; PAI; Serine or Cysteine Proteinase Inhibitor Clade E Member 1; Nexin; Plasminogen Activator Inhibitor-1;

NCIt definition : Plasminogen activator inhibitor 1 (402 aa, 45 kDa) is encoded by the human SERPINE1 gene. This protein plays a role in both cell adhesion and the modulation of plasmin activity.;

NCIt note : Plasminogen Activator Inhibitor-1 is a member of the serpin superfamily that inhibits both tissue-type and urokinase-type plasminogen activators. PAI1 shows structural similarities to angiotensinogen, alpha-1-antitrypsin, and antithrombin III and also regulates motility through the interaction of vitronectin with its receptor, integrin alpha-V-beta-3. (from OMIM 173360);

Details

Origin ID

C16947;

UMLS CUI

C1620101;

Currated CISMeF NLP mapping
- Nexin [FMA entity]
- Plasminogen activator inhibitor 1 [LOINC component]
- Plasminogen activator inhibitor-1 (substance) [SNOMED CT concept]
- plasminogen activator inhibitor 1 [MeSH Descriptor]
- plasminogen activator inhibitor 1 [MeSH concept]
- plasminogen activator inhibitor-1 [SNOMED Notion]
- plasminogen activator inhibitors, endothelial [MeSH concept]
OMIM relation
- Serpin peptidase inhibitor, clade e (nexin, plasminogen activator inhibitor type 1), member 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SERPINE1 protein, human [MeSH concept]
- SERPINE1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Inhibitor Gene [NCIt concept]
- Proteinase Inhibitor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- SERPINE1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Serpin [NCIt concept]
gene_product_has_chemical_classification
- Serpin [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Enzyme Inhibition [NCIt concept]
- Regulation of Proteolysis [NCIt concept]
is_target
- PAI-1 Inhibitor ACT001 [NCIt concept]

Keyword's position in hierarchy(ies) :

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