Interleukin-1 Receptor-Associated Kinase 4

Preferred Label : Interleukin-1 Receptor-Associated Kinase 4;

NCIt synonyms : REN64; IRAK4; Renal Carcinoma Antigen NY-REN-64; EC 2.7.11.1; Interleukin-1 Receptor-Associated Kinase-4;

NCIt definition : Interleukin-1 receptor-associated kinase 4 (460 aa, 52 kDa) is encoded by the human IRAK4 gene. This protein plays a role in the initiation of the immune response against pathogens.;

Details

Origin ID

C29752;

UMLS CUI

C1334203;

Currated CISMeF NLP mapping
- Interleukin-1 Receptor-Associated kinase 4 [MeSH concept]
OMIM relation
- Interleukin 1 receptor-associated kinase 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- IRAK4 protein, human [MeSH Supplementary Concept]
- IRAK4 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- IRAK4 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Chagas Disease Pathway [NCIt concept]
- IL1-Mediated Signaling Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Immune Response Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Dual IRAK1/4 Inhibitor R906289 Monosodium [NCIt concept]
- Emavusertib [NCIt concept]
- Emavusertib Hydrochloride [NCIt concept]
- IRAK4/Ikaros/Aiolos Protein Degrader KT-413 [NCIt concept]
- Zimlovisertib [NCIt concept]

Keyword's position in hierarchy(ies) :

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