Preferred Label : Emavusertib Hydrochloride;
NCIt synonyms : AU-4948 Hydrochloride; CA 4948 Hydrochloride; AU 4948 Hydrochloride;
NCIt definition : The hydrochloriden salt form of emavusertib, an orally bioavailable, reversible inhibitor
of interleukin-1 receptor-associated kinase 4 (IRAK4), with potential antineoplastic,
immunomodulating and anti-inflammatory activities. Upon oral administration, emavusertib
targets, binds to, and blocks the kinase activity of IRAK4. This inhibits IRAK4-mediated
signaling, prevents the activation of IRAK4-mediated nuclear factor-kappa B (NF-kB)
signaling and decreases the expression of inflammatory cytokines and certain pro-survival
factors. This inhibits proliferation of IRAK4-overactivated tumor cells, which are
found in cells harboring MYD88 activating mutations or those with overactivated toll-like
receptor (TLR) pathways. In addition, CA-4948 may inhibit inflammation and immune-mediated
cell destruction in inflammatory and auto-immune diseases where TLR or interleukin
1 receptor (IL-1R) signaling is overactivated and MYD88 is dysregulated. IRAK4, a
serine/threonine-protein kinase that plays a key role in both the TLR and IL-1R signaling
pathways, is activated though the adaptor protein MYD88 and links the TLR and IL-1R
signaling pathway to the NF-kB pathway.;
UNII : 2X6Q4LZ6WL;
CAS number : 2376399-42-5;
NCI Metathesaurus CUI : CL1798509;
Origin ID : C189979;
UMLS CUI : C5708857;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
