B2 Bradykinin Receptor

Preferred Label : B2 Bradykinin Receptor;

NCIt synonyms : BDKRB2; BK-2; BK2; BKR2; BRB2; B2R; Bradykinin Receptor-B2; Bradykinin Receptor B2; Bradykinin Receptor 2; BK-2 Receptor;

NCIt definition : B2 bradykinin receptor (391 aa, 44 kDa) is encoded by the human BDKRB2 gene. This protein plays a role in bradykinin binding and receptor signaling.;

NCIt note : Bradykinin Receptor B2, encoded by the BDKRB2 gene, is a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein.;

Details

Origin ID

C26101;

UMLS CUI

C4048586;

Currated CISMeF NLP mapping
- receptor, bradykinin B2 [MeSH concept]
- receptor, bradykinin b2 [MeSH Descriptor]
OMIM relation
- Bradykinin receptor b2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
gene_encodes_gene_product
- BDKRB2 Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Angiogenesis Pathway [NCIt concept]
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Complement and Coagulation Cascade [NCIt concept]
- Corticosteroid Cardioprotection Pathway [NCIt concept]
- Ion Channels in Vascular Endothelium Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- Nitric Oxide Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Calcium Signaling [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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