AKT3 wt Allele

Preferred Label : AKT3 wt Allele;

NCIt synonyms : DKFZP434N0250; PKBG; PRKBG; MPPH2; RAC-GAMMA; MPPH; RAC-PK-Gamma; AKT Serine/Threonine Kinase 3 wt Allele; PKB-GAMMA; STK-2; v-akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) Gene;

NCIt definition : Human AKT3 wild-type allele is located within 1q43-q44 and is approximately 355 kb in length. This allele, which encodes RAC-gamma serine/threonine-protein kinase protein, plays a role in the regulation of cell signaling in response to insulin and growth factors. AKT3 gene amplification and overexpression are associated with progression of malignant melanoma.;

NCIt note : The AKT3 gene is highly expressed in the brain, fetal heart, kidneys, liver and lungs. This gene undergoes alternative splicing to produce four RNA transcript variants that yield four corresponding protein isoforms.;

GenBank Accession Number : NM_005465;

Details

Origin ID

C51188;

UMLS CUI

C1706657;

OMIM relation
- Akt serine/threonine kinase 3 [OMIM gene]
See also inter- (CISMeF)
- Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 [OMIM Phenotype]
- Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 [OMIM Phenotype]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 1: 240332594-239977576 [NCIt concept]
gene_in_chromosomal_location
- 1q43-q44 [NCIt concept]
gene_is_element_in_pathway
- Acute Myeloid Leukemia Pathway [NCIt concept]
- Adipocytokine Signaling Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- B Cell Receptor Signaling Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- Endometrial Cancer Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Inositol Phosphate Metabolism Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Nicotinate and Nicotinamide Metabolism Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- PI3K/AKT1 Signaling Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Progesterone-Mediated Oocyte Maturation Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
- Small Cell Lung Cancer Pathway [NCIt concept]
- Sphingolipid Metabolism Pathway [NCIt concept]
- Sphingosine 1-Phosphate Receptor 3 Signaling Pathway [NCIt concept]
- Starch and Sucrose Metabolism Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- Tight Junction Assembly Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- VEGF Signaling Pathway [NCIt concept]
- mTOR Signaling Pathway KEGG [NCIt concept]
gene_plays_role_in_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- Intermediary Metabolic Process [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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