CCN Family Member 2

Preferred Label : CCN Family Member 2;

NCIt synonyms : Hypertrophic Chondrocyte-Specific Protein 24; Insulin-Like Growth Factor-Binding Protein 8; Connective Tissue Growth Factor Protein; IBP-8; IGF-Binding Protein 8; IGFBP-8; CTCF; CCN2; Connective Tissue Growth Factor; Cellular Communication Network Factor 2; CTGF;

NCIt definition : CCN family member 2 (349 aa, 38kDa) is encoded by the human CCN2 gene. This protein plays a role in the promotion of proliferation and differentiation of chondrocytes and also mediates heparin- and divalent cation-dependent cell adhesion in many different cell types.;

Details

Origin ID

C62460;

UMLS CUI

C1137457;

OMIM relation
- Cellular communication network factor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CCN2 protein, human [MeSH concept]
- CCN2 protein, human [MeSH Supplementary Concept]
- Connective tissue growth factor [LOINC component]
- Connective tissue growth factor (substance) [SNOMED CT concept]
- connective tissue growth factor [MeSH Descriptor]
- connective tissue growth factor [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CCN2 Gene [NCIt concept]
- Growth Factor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Heparin Binding Growth Factor [NCIt concept]
gene_product_has_chemical_classification
- CCN Family Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Risk Marker [NCIt concept]
gene_product_is_element_in_pathway
- AlphaM/Beta2 Integrin Signaling Pathway [NCIt concept]
- TGF Beta Signaling Pathway BioCarta [NCIt concept]
- TGF-Beta Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Heparin Binding [NCIt concept]
- Intracellular Signaling Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Transport Process [NCIt concept]
is_target
- Pamrevlumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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