Mothers Against Decapentaplegic Homolog 7

Preferred Label : Mothers Against Decapentaplegic Homolog 7;

NCIt synonyms : SMA- and MAD-Related Protein 7; Mothers Against Decapentaplegic Homolog 7 Protein; Mothers Against DPP Homolog 7 Protein; Mothers Against Decapentaplegic, Drosophila, Homolog 7 Protein; hSMAD7; MAD (Mothers Against Decapentaplegic, Drosophila) Homolog 7 Protein; MADH7; Smad7; SMAD7 Protein; Mothers Against Decapentaplegic Homolog 8; SMAD 7; Mothers Against DPP Homolog 7; Mothers Against DPP Homolog 8; MAD Homolog 8; MAD Homolog 7;

NCIt definition : Mothers against decapentaplegic homolog 7 (426 aa, 46 kDa) is encoded by the human SMAD7 gene. This protein plays a role in the attenuation of transforming growth factor-beta type-1 receptor signal transduction.;

NCIt note : Mothers against decapentaplegic homolog 7 (SMAD7) is a nuclear protein that translocates to the cytoplasm after binding to the E3 ubiquitin ligase SMURF2. In the cytoplasm, this complex catalyzes the ubiquitination and promotes the subsequent degradation of both TGF-beta receptor type-1 and SMAD7.;

Details

Origin ID

C26482;

UMLS CUI

C1566818;

Currated CISMeF NLP mapping
- Smad7 protein [MeSH concept]
- smad7 protein [MeSH Descriptor]
OMIM relation
- Smad family member 7 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SMAD7 protein, human [MeSH Supplementary Concept]
- SMAD7 protein, human [MeSH concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- SMAD7 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- BMP Receptor Signaling Pathway [NCIt concept]
- HDAC Class I Signaling Pathway [NCIt concept]
- Interferon-Gamma Signaling Pathway [NCIt concept]
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
- TGF Beta Signaling Pathway BioCarta [NCIt concept]
- TGF-Beta Receptor Signaling Pathway [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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