Ribosomal Protein S6 Kinase Beta-2

Preferred Label : Ribosomal Protein S6 Kinase Beta-2;

NCIt synonyms : Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2; RPS6KB2; p70 Ribosomal S6 Kinase Beta; S6K-Beta 2; p70-Beta; 70 kDa Ribosomal Protein S6 Kinase 2; SRK; p70 S6K Beta; Serine/Threonine-Protein Kinase 14 Beta; p70S6KB; p70-S6KB; S6 Kinase-Related Kinase; S6K2; Serine/Threonine-Protein Kinase 14 B; S6K-Beta; S6K-Beta-2; p70 S6 Kinase Beta; Ribosomal Protein S6 Kinase Beta 2; p70 S6K-Beta; p70-S6K 2; p70 S6KB;

NCIt definition : Ribosomal protein S6 kinase beta-2 (482 aa, 53 kDa) is encoded by the human RPS6KB2 gene. This protein is involved in serine/threonine protein phosphorylation.;

NCIt note : Ribosomal Protein S6 Kinase Beta 2 specifically phosphorylates 40S ribosomal protein S6, the major eukaryotic ribosome substrate of many kinases. S6 phosphorylation is stimulated by growth factors and mitogens; dephosphorylation occurs at growth arrest. S6 may control cell growth and proliferation through the selective translation of specific of mRNA classes.;

Details

Origin ID

C29911;

UMLS CUI

C5441898;

Currated CISMeF NLP mapping
- ribosomal protein S6 kinase beta 2 [MeSH concept]
OMIM relation
- Ribosomal protein s6 kinase b2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- ribosomal protein S6 kinase, 70kD, polypeptide 2 [MeSH concept]
- ribosomal protein S6 kinase, 70kD, polypeptide 2 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- RPS6KB2 Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Acute Myeloid Leukemia Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
- mTOR Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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