CCAAT/Enhancer Binding Protein Alpha

Preferred Label : CCAAT/Enhancer Binding Protein Alpha;

NCIt synonyms : CEBPA; CEBP Alpha; C/EBP Alpha; CEBP; CCAAT-Enhancer Binding Protein Alpha;

NCIt definition : CCAAT/enhancer binding protein alpha (358 aa, 38 kD) is encoded by the human CEBPA gene. This nuclear protein is a DNA-binding bZIP transcription factor that, as a homodimer, recognizes common motifs in both the promoter (CCAAT sequence) and enhancer (core homology sequence) regions of genes.;

NCIt note : CEBPA protein binds to the leptin gene promoter and modulates expression of the leptin protein, which is important in body weight homeostasis. CEBPA protein interacts with CDK2 and CDK4, thereby inhibiting kinase activity which results in cell growth arrest. This protein also plays an important role in the differentiation of immature granulocytes.;

Details

Origin ID

C45488;

UMLS CUI

C1872854;

Currated CISMeF NLP mapping
- CCAAT-Enhancer-Binding protein-alpha [MeSH concept]
- ccaat-enhancer-binding protein-alpha [MeSH Descriptor]
OMIM relation
- Ccaat/enhancer-binding protein, alpha [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CCAAT-Enhancer-Binding protein-alpha [MeSH concept]
- CEBPA protein, human [MeSH Supplementary Concept]
- CEBPA protein, human [MeSH concept]
- ccaat-enhancer-binding protein-alpha [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CEBPA Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- CCAAT Enhancer Binding Protein [NCIt concept]
- DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- bZIP Domain [NCIt concept]
gene_product_is_element_in_pathway
- Acute Myeloid Leukemia Pathway [NCIt concept]
- Androgen Receptor Regulation Pathway [NCIt concept]
- E2F Transcription Factor Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Acute Myeloid Leukemia with CEBPA Mutation [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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