MAP3K8 wt Allele

Preferred Label : MAP3K8 wt Allele;

NCIt synonyms : c-COT; Cancer Osaka Thyroid Gene; COT; Augmented in Rheumatoid Arthritis 2 Gene; Mitogen-Activated Protein Kinase Kinase Kinase 8 wt Allele; COT (Cancer Osaka Thyroid) Oncogene; COT Gene; Proto-Oncogene Serine/Threoine Protein Kinase Gene; EST; Cancer Osaka Thyroid Oncogene; TPL-2; ESTF; Tumor Progression Locus 2 Gene; TPL2; MEKK8; Ewing Sarcoma Transformant Gene; Tumor Progression Locus-2 Gene; AURA2; Oncogene COT Gene;

NCIt definition : Human MAP3K8 wild-type allele is located in the vicinity of 10p11.23 and is approximately 28 kb in length. This allele, which encodes mitogen-activated protein kinase kinase kinase 8 protein, is pleiotropic due to its role in several signaling pathways that are involved in processes such as cell cycle regulation and T-cell activation.;

NCIt note : The MAP3K8 gene encodes two isoforms of mitogen-activated protein kinase kinase kinase 8 protein via alternative initiation.;

GenBank Accession Number : NM_005204;

Details

Origin ID

C51214;

UMLS CUI

C1705156;

OMIM relation
- Mitogen-activated protein kinase kinase kinase 8 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_associated_with_disease
- Lung Adenocarcinoma [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 10p12.1 [NCIt concept]
gene_is_element_in_pathway
- MAPKinase Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Cycle Regulation Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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