" /> Microphthalmia-Associated Transcription Factor - CISMeF





Preferred Label : Microphthalmia-Associated Transcription Factor;

NCIt synonyms : Class E Basic Helix-Loop-Helix Protein 32; bHLHe32; MITF;

NCIt definition : Microphthalmia-associated transcription factor (526 aa, 59 kDa) is encoded by the human MITF gene. This protein is involved in the transcription of genes that encode melanogenic enzymes.;

NCIt note : Microphthalmia-associated transcription factor binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') found in the tyrosinase promoter. (UniProt); Microphthalmia-associated transcription factor is a basic helix-loop-helix (bHLH) protein. This protein requires homodimerization or heterodimerization with another bHLH-containing protein for efficient binding to a DNA target.;

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29/07/2025


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