IL17 Signaling Pathway

Preferred Label : IL17 Signaling Pathway;

NCIt related terms : IL 17 Signaling Pathway;

Alternative definition : BIOCARTA: Inflammation is a complex response involving many different cells and signaling molecules, including the secretion of the cytokine IL-17 by activated T cells. IL-17 secretion is restricted to specific subsets of T cells but the receptor for IL-17 is widely expressed throughout the body, including fibroblasts and epithelial cells. Inflammatory responses involving IL-17 probably contribute to arthritis, asthma, skin immune reactions, and autoimmune disorders. Fibroblasts and other cells stimulated by IL-17 are induced themselves to secrete inflammatory and hematopoietic cytokines, including IL-6, IL-8, G-CSF, and Stem Cell Factor (SCF). These cytokines in turn provoke a range of activities, including the stimulation of neutrophil proliferation and differentiation. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_il17Pathway;

Details

Origin ID

C39118;

UMLS CUI

C1512589;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- Granulocyte Colony-Stimulating Factor [NCIt concept]
- Hematopoietic Progenitor Cell Antigen CD34 [NCIt concept]
- Interleukin-17A [NCIt concept]
- Interleukin-3 [NCIt concept]
- Interleukin-6 [NCIt concept]
- Interleukin-8 [NCIt concept]
- Kit Ligand [NCIt concept]
- Lymphocyte Function-Associated Antigen 3 [NCIt concept]
- T-Cell Surface Antigen CD2 [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Delta Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Epsilon Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Gamma Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Zeta Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD4 [NCIt concept]
- T-Cell Surface Glycoprotein CD8 Alpha Chain [NCIt concept]
pathway_has_gene_element
- CD2 wt Allele [NCIt concept]
- CD247 wt Allele [NCIt concept]
- CD34 wt Allele [NCIt concept]
- CD3D wt Allele [NCIt concept]
- CD3E wt Allele [NCIt concept]
- CD3G wt Allele [NCIt concept]
- CD4 wt Allele [NCIt concept]
- CD58 wt Allele [NCIt concept]
- CSF3 wt Allele [NCIt concept]
- CXCL8 wt Allele [NCIt concept]
- IL17A wt Allele [NCIt concept]
- IL3 wt Allele [NCIt concept]
- IL6 wt Allele [NCIt concept]
- KITLG wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients