Interleukin-17A

Preferred Label : Interleukin-17A;

NCIt synonyms : Interleukin-17; Cytotoxic T-Lymphocyte-Associated Antigen 8; IL-17A; CTLA-8; Interleukin 17 Precursor; CTLA8; Interleukin 17; IL17; Cytotoxic T-Lymphocyte-Associated Serine Esterase 8; IL17 Protein; IL17A; IL-17;

NCIt definition : Interleukin-17A (155 aa, 18 kDa) is encoded by the human IL17A gene. This protein is involved in the positive regulation of cytokine production.;

NCIt note : Interleukin-17A enhances expression of IL6, IL8, and ICAM-1 in fibroblasts, regulates the activities of NF-kappaB and mitogen-activated protein kinases, stimulates the expressionn cyclooxygenase-2 (PTGS2/COX-2), enhances the production of nitric oxide (NO) and appears to induce osteoclastogenesis and ODF, a membrane-associated protein essential to osteoclast differentiation.;

Details

Origin ID

C20519;

UMLS CUI

C1701790;

False automatic mappings
- Interleukin-17F [MeSH concept]
OMIM relation
- Interleukin 17a [OMIM gene]
See also inter- (CISMeF)
- Interleukin 17a [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- IL17A protein, human [MeSH concept]
- IL17A protein, human [MeSH Supplementary Concept]
Validated automatic mappings to NTBT
- Interleukin-17 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- IL17A Gene [NCIt concept]
- Interleukin Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- IL17 Signaling Pathway [NCIt concept]
- IL23-Mediated Signaling Pathway [NCIt concept]
- IL27-Mediated Signaling Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Multiple Sclerosis [NCIt concept]
- Psoriasis [NCIt concept]
- Rheumatoid Arthritis [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]
is_target
- Anti-IL17A Monoclonal Antibody CJM112 [NCIt concept]

Keyword's position in hierarchy(ies) :

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