NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody against the pro-inflammatory
cytokine interleukin 17A (IL-17A; IL-17), with potential anti-inflammatory activity.
Upon subcutaneous administration, anti-IL17A monoclonal antibody CJM112 selectively
targets and binds to IL-17A, thereby neutralizing the IL-17A protein. This prevents
binding of IL-17A to the IL-17 receptor (IL-17R), and inhibits IL-17A/IL-17R-mediated
signaling and inflammation mediated by this pathway. IL-17A is mainly produced by
inflammatory T helper 17 cells (Th17), and certain lymphocytes. IL-17A production
is upregulated in many immune-mediated inflammatory diseases, such as psoriasis and
multiple sclerosis (MS), and plays a key role in the development of inflammation and
the immune response.;
Semantic type(s)