Lymphocyte Function-Associated Antigen 3

Preferred Label : Lymphocyte Function-Associated Antigen 3;

NCIt synonyms : CD58 Antigen; LFA-3; MSK2; CD2 Ligand; CD58; Ag3; Surface Glycoprotein LFA-3; Lymphocyte Function-Associated Antigen-3;

NCIt definition : Lymphocyte function-associated antigen 3 (250 aa, 28 kDa) is encoded by the human CD58 gene. This protein is involved in the adhesion and activation of T-lymphocytes.;

NCIt note : CD58 mediates cell adhesion by binding to CD2 (ANTIGENS, CD2) and this enhances antigen-specific T-cell activation.;

Details

Origin ID

C17403;

UMLS CUI

C4082565;

Currated CISMeF NLP mapping
- CD58 Antigens [MeSH Descriptor]
- CD58 Antigens [MeSH concept]
- Lymphocyte antigen CD58 (substance) [SNOMED CT concept]
OMIM relation
- Cd58 antigen [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
gene_encodes_gene_product
- CD58 Gene [NCIt concept]
- Cell Adhesion Molecule Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Epithelial Cell [NCIt concept]
- Erythrocyte [NCIt concept]
- Fibroblast [NCIt concept]
- Leukocyte [NCIt concept]
gene_product_has_associated_anatomy
- Endothelial Cell [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
- IL17 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell-Cell Adhesion Process [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immune Response Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Protein-Protein Interaction [NCIt concept]

Keyword's position in hierarchy(ies) :

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