T-Cell Surface Antigen CD2

Preferred Label : T-Cell Surface Antigen CD2;

NCIt synonyms : Sheep Red Blood Cell Receptor; CD2 Antigen; Lymphocyte-Function Antigen-2; E-Rosette Receptor; CD2R; Erythrocyte Receptor; LFA-2; LFA-3 Receptor; Sheep Erythrocyte Receptor; T-Cell Surface Antigen T11/Leu-5; Rosette Receptor; T-Lymphocyte Surface CD2 Antigen;

NCIt related terms : CD2;

NCIt definition : T-cell surface antigen CD2 (351 aa, 39 kDa) is encoded by the human CD2 gene. This protein plays a role in both T-cell activation and T-cell adhesion to other cells.;

NCIt note : An antigen that functions as a co-receptor or accessory molecule in the T-cell receptor complex, which is involved in helper and cytotoxic T-lymphocyte adhesion and activation. The molecule is expressed on the cell surface of the majority of peripheral T-lymphocytes, NK cells, and thymocytes.;

Details

Origin ID

C15174;

UMLS CUI

C5441935;

Automatic exact mappings (from CISMeF team)
- CD2 [LOINC component]
- CD2 cells [LOINC component]
- T-lymphocyte surface cd2 antigen [OMIM gene]
OMIM relation
- T-lymphocyte surface cd2 antigen [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CD2 Gene [NCIt concept]
- Cell Adhesion Molecule Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Alefacept [NCIt concept]
- Monoclonal Antibody 95-5-49 [NCIt concept]
gene_product_expressed_in_tissue
- Natural Killer Cell [NCIt concept]
- T-Lymphocyte [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Immunoglobulin-Like V-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
- Cytotoxic T Cell Surface Pathway [NCIt concept]
- Dendritic Cell Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- IL17 Signaling Pathway [NCIt concept]
- NO2-Dependent IL12 Pathway [NCIt concept]
- Stathmin Pathway [NCIt concept]
- T Helper Cell Surface Molecule Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cell Adhesion Process [NCIt concept]
- Cell-Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]
- T-Cell Activation [NCIt concept]
is_target
- Alefacept [NCIt concept]
- Monoclonal Antibody 95-5-49 [NCIt concept]

Keyword's position in hierarchy(ies) :

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