CD34 wt Allele

Preferred Label : CD34 wt Allele;

NCIt synonyms : HPCA1; CD34 Antigen wt Allele;

NCIt definition : Human CD34 wild-type allele is located within 1q32 and is approximately 40 kb in length. This allele, which encodes hematopoietic progenitor cell antigen CD34 immunoprotein, is involved in hematopoiesis and may mediate bone marrow extracellular matrix or stroma scaffold interactions. Aberrant expression of the allele is associated with leukemogenesis.;

NCIt note : Expression is analyzed as part of the 17-gene leukemia stem cell scoring system (LSC17). (Nature. 2016; doi:10.1038/nature20598.);

GenBank Accession Number : NM_001773;

Details

Origin ID

C51121;

UMLS CUI

C1707098;

OMIM relation
- Cd34 antigen [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 1: 204472910-204448280 [NCIt concept]
gene_in_chromosomal_location
- 1q32 [NCIt concept]
gene_is_element_in_pathway
- IL17 Signaling Pathway [NCIt concept]
- Lymphocyte Adhesion Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Adhesion Process [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Ligand Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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