Endothelin-1 - CISMeF

Preferred Label : Endothelin-1;

NCIt synonyms : EDN1; Endothelin 1; ET-1; Preproendothelin-1; PPET1; Preproendothelin 1;

NCIt definition : Endothelin-1 (212 aa, 24 kDa) is encoded by the human EDN1 gene. This protein is involved in vasoconstriction.;

NCIt note : Endothelin-1 is proteolytically processed to form big endothelin-1 (38 amino acids) or a 21 amino acid peptide also called endothelin-1. The active forms inhibits active Na-K transport by inhibiting Na( )-K( )-ATPase in intact renaltubular epithelial cells.;

Details

Origin ID

C1285;

UMLS CUI

C4316927;

Automatic exact mappings (from CISMeF team)
- Endothelin 1 [OMIM gene]
- Preproendothelin-1 [MeSH concept]
False automatic mappings
- endothelin-1 (1-21) [MeSH concept]
- endothelin-1 (1-21) [MeSH Supplementary Concept]
- endothelin-1 (1-31) [MeSH concept]
- endothelin-1 (1-31) [MeSH Supplementary Concept]
OMIM relation
- Endothelin 1 [OMIM Phenotype]
See also inter- (CISMeF)
- endothelin 1 [ORDO Gene]
- endothelin 1 [HGNC gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- EDN1 Gene [NCIt concept]
- Peptide Hormone Gene [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Cardiac Hypertrophy Pathway [NCIt concept]
- Hypoxia-Inducible Factor Pathway [NCIt concept]
- Melanogenesis Pathway [NCIt concept]
- NFAT Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Hypertension [NCIt concept]
gene_product_plays_role_in_biological_process
- Intercellular Communication Process [NCIt concept]
- Transport Process [NCIt concept]
is_target
- Ofranergene Obadenovec [NCIt concept]

Keyword's position in hierarchy(ies) :

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