Preferred Label : Ofranergene Obadenovec;
NCIt definition : A non-replicating adenovirus 5 (Ad-5, El-deleted) encoding a human Fas-chimera (Fas-c)
transgene under the control of a modified murine pre-proendothelin-1 (PPE-1) promoter,
with potential anti-angiogenic activity. Upon the administration of ofranergene obadenovec,
the modified murine PPE-1 promoter is specifically activated in PPE-1-expressing angiogenic
endothelial cells residing in the tumor microvasculature. Subsequently, the Fas-c
pro-apoptotic transgene, containing the human tumor necrosis factor (TNF) receptor
1 (TNFR-1/p55) and the signaling domain of Fas, is expressed in angiogenic endothelial
cells. Fas-mediated apoptosis is activated via binding of the TNFR-1 receptor with
TNF-alpha, which is more abundant in the tumor microenvironment (TME), enhancing specificity
and limiting systemic toxicities.;
UNII : 5Q5PRH05GI;
CAS number : 1476737-24-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1476737-24-2
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G-SRS /a ;
Molecule name : GT-111; VB-111;
NCI Metathesaurus CUI : CL378317;
Origin ID : C71539;
UMLS CUI : C5139853;
Semantic type(s)
- concept_is_in_subset
- has_target
