Frizzled-3 - CISMeF

Preferred Label : Frizzled-3;

NCIt synonyms : Frizzled 3 Protein; Frizzled 3; FZD3; Fz-3; Frizzled Homolog 3; FZD3 Protein; hFz3; Frizzled-3 Protein; Frizzled Family Receptor 3;

NCIt definition : Frizzled-3 (666 aa, 76 kDa) is encoded by the human FZD3 gene. This protein plays a role in Wnt-dependent G protein-coupled receptor signaling;

NCIt note : Frizzled 3, encoded by the human FZD3 gene, is a G protein-coupled receptor for Wnt proteins and regulates signal transduction in endothelial cells via beta-catenin. It may function in both normal and pathological vasculature differentiation. It also may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Two isoforms are produced by alternative splicing. This protein is widely expressed with relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis. (From LocusLink, Swiss-Prot and NCI);

Details

Origin ID

C26165;

UMLS CUI

C1175384;

OMIM relation
- Frizzled class receptor 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- FZD3 protein, human [MeSH concept]
- FZD3 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- FZD3 Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Frizzled Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Basal Cell Carcinoma Pathway [NCIt concept]
- Melanogenesis Pathway [NCIt concept]
- Wnt Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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