Suppression of Tumorigenicity 5 Protein

Preferred Label : Suppression of Tumorigenicity 5 Protein;

NCIt synonyms : DENND2B Isoform 1; Suppression of Tumorigenicity 5; Suppressor of Tumorigenicity 5; Suppression of Tumorigenicity 5 Protein Isoform 1; ST5; p126; HeLa Tumor Suppression 1 Protein; ST5 Protein; DENN Domain-Containing Protein 2B; DENND2B; HeLa Tumor Suppression 1;

NCIt definition : Suppression of tumorigenicity 5 protein (1137 aa, 126 kDa) is encoded by the human DENND2B gene. This protein plays a role in the cytoskeletal organization, EGFR trafficking/recycling and activation of the MAPK1 pathway.;

Details

Origin ID

C18284;

UMLS CUI

C1429778;

Currated CISMeF NLP mapping
- ST5 (body structure) [SNOMED CT concept]
OMIM relation
- Suppressor of tumorigenicity 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- DENND2B protein, human [MeSH Supplementary Concept]
- DENND2B protein, human [MeSH concept]
gene_encodes_gene_product
- DENND2B Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Endosome [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_structural_domain_or_motif
- Proline-Rich Domain [NCIt concept]
gene_product_is_element_in_pathway
- Protein Cycling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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