B-Cell Linker Protein

Preferred Label : B-Cell Linker Protein;

NCIt synonyms : BLNK; B Cell Linker Protein; B Cell-Specific Adaptor Protein; B-Cell Linker; B-Cell Adapter Containing a Src Homology 2 Domain Protein; SH2 Domain-Containing Leukocyte Protein, 65-kD; Src Homology [SH2] Domain-Containing Leukocyte Protein of 65 kD; B Cell Adaptor Containing SH2 Domain; B-Cell Adapter Containing a SH2 Domain Protein; Cytoplasmic Adapter Protein; SLP-65; Src Homology 2 Domain-Containing Leukocyte Protein of 65 kDa;

NCIt definition : B-cell linker protein (456 aa, 50 kDa) is encoded by the human BLNK gene. This protein is involved in co-localizing the B-cell receptor and its downstream signaling targets.;

NCIt note : B-cell linker protein interfaces the B-cell receptor-associated SYK tyrosine kinase with PLC-gamma, the VAV guanine nucleotide exchange factor, and the GRB2 and NCK adaptor proteins. Tyrosine phosphorylation of B-cell linker protein by SYK provides docking sites for these SH2-containing effector molecules that, in turn, permits the phosphorylation and/or activation of their respective signaling pathways.;

Details

Origin ID

C26636;

UMLS CUI

C1740182;

Currated CISMeF NLP mapping
- B cell linker protein [MeSH concept]
- B cell linker protein [MeSH Supplementary Concept]
OMIM relation
- B-cell linker protein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BLNK protein, human [MeSH concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- BLNK Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_expressed_in_tissue
- B-Lymphocyte [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Proline-Rich Domain [NCIt concept]
- SH2 Domain [NCIt concept]
gene_product_is_element_in_pathway
- B Cell Receptor Signaling Pathway [NCIt concept]
- BCR Signaling Pathway [NCIt concept]
- Primary Immunodeficiency Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Childhood B Acute Lymphoblastic Leukemia [NCIt concept]
gene_product_plays_role_in_biological_process
- B-Cell Differentiation [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]

Keyword's position in hierarchy(ies) :

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